FY21 Core Facility Pricing
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
Consultations/Project Management DTC personnel provides hourly based consultation related to model selection, formulation, the experimental details (designs, groups, and endpoints). Add 1h/wk for each week of the study for emails, zooms. Phone calls, study updates for the duration of the experiment |
$130 | $114 | $195 | $260 |
| Animal Protocol Creation DTC will create a new IACUC animal protocol (from submission to approval) to include all aims related to in vivo experiments for the requested project. |
$1,500 | $1,350 | $2,250 | $3,000 |
| IACUC Addendums Drafting and submitting new experimental procedure addendum to an existing DTC-owned IACUC protocol |
$400 | $360 | $600 | $800 |
| Data Analysis Analyzing data, performing statistical analysis, generating graphs, and PowerPoint presentation. |
$130 | $117 | $195 | $260 |
| Weekend Work DTC personnel will perform study related tasks over the weekend (administration of compound, animal monitoring, etc.) as required by the study design. Service cost is per hour. |
$195 | $175.50 | $290 | $350 |
| Technician Time DTC technician hourly rate. |
$130 | $114 | $195 | $260 |
| Sample Storage – Ambient Temperature DTC will store the samples in the facility for a monthly fee. |
$30 | $27 | $45 | $60 |
| Sample Storage – Freezer DTC will store the sample box in the freezer for a monthly fee. |
$50 | $45 | $75 | $100 |
| Shipping Box preparation (ambient temp, ice, or dry ice) for shipping samples domestically. |
$65 | $58.50 | $65 | $65 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
Body Weight, Health Monitoring, or Tumor Volume Measurement Daily side cage monitoring, and twice per week animal body weight (3 min/mouse, 5 min/rat, 5 min/rabbit), and tumor volume measurements ($5/animal) |
$130 | $117 | $195 | $260 |
| Euthanasia $45 for euthanasia + $10 for blood collection. $5 charge will apply for each organ collection (extra for brain/region dissection) |
$45 | $40.50 | 67.50 | $90 |
| Xenograft Orthotopic Setup DTC personnel will set up the animal orthotopic cancer model using immortalized cell or PDX lines/organoids |
$1,500 | $1,350 | $2,250 | $3,000 |
| Xenograft Heterotopic Setup DTC personnel will set up the animal heterotopic cancer model using immortalized cell or PDX lines/organoids |
$1,000 | $900 | $1,500 | $2,000 |
| IVIS Imaging DTC service charge for the time spent to operate bioluminescence imaging instrument (IVIS) to monitor tumor growth. Instrument usage cost is a separate CAMI passthrough charge |
$130 | $117 | $195 | $260 |
| IVIS Image Analysis $10/animal/each time point |
$10 | $9 | $15 | $20 |
| Metastic Xenograph Model Setup DTC personnel will set up the animal heterotopic cancer model using immortalized cell or PDX lines/organoids. Once the tumor volumes has reached to requred size, the tumor is surgically removed and the animal is recuited for therapy or efficacy studies/projects. The cost for the efficay study is a separate charge. |
$0 | $180 | $300 | $400 |
| Disease Models DTC staff can help investigators develop or execute animal experiments for various disease models (inflammatory, neurodegenerative, pain, etc.). Charges will vary depending on specific model. Technician time is $130/hr. |
$130 | $117 | $195 | $260 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
In Vivo Tumor Model Testing Cost associated with compound testing in a xenograft (heterotopic or orthotropic) tumor model. The service includes: tumor induction and 1 orally-administered compound. For extra treatments use service 3. Weekend treatments are extra. The service also includes twice per week body weight and tumor volume (caliper) measurements. Additional charges will apply for whole body imaging (IVIS). The service is offered for a 6-weeks study (1-2 weeks tumor development, 2-3 weeks treatment, 2-3 weeks post-treatment observation). Studies longer than 6 weeks will be charged extra. |
$0 | $1,800 | $3,000 | $4,000 |
| Cell Lines Culture – Adhered DTC personnel will culture cells (from DTC inventory guaranteed mycoplasma-free cell lines) and will ensure sufficient number of cells per given experiment. Charge is based on final # of T-75 flasks needed per experiment. |
$275 | $247.50 | $400 | $550 |
| Cell Line Culture – Suspension DTC personnel will culture cells (from DTC inventory guaranteed mycoplasma-free cell lines) and will ensure sufficient number of cells per given experiment. Charge is based on final # of T-75 flasks of tumor cells/experiment. |
$0 | $360 | $500 | $800 |
| Proliferation Assay Modified cytotoxicity study/proliferation assay (12 cell lines from different tumor histologies) for up to 30 compounds screened at a single concentration and up to 5 compounds tested in a dose response study (5 concentrations) for IC50 determination. For a single cell line, minimum of 5 compounds are required if tested at a single concentration. |
$100 | $90 | $150 | $200 |
| Proliferation Assay – IC50 Service to provide compound IC50 (n=8 concentrations) per compound per cell line. |
$275 | $247.50 | $400 | $525 |
| Spheroid Formation Assay 3D spheroid assay development (tumor cells or neural progenitor cell). $500/culture |
$2,500 | $2,250 | $3,700 | $4,500 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
Mice Immunization DTC personnel will immunize mice per IACUC protocol instruction. The cost will include: 1 inoculation, 3 boosters, 2 in-life and 1 terminal blood collections. |
$1,600 | $1,440 | $2,400 | $3,000 |
| Rabbit Immunization DTC personnel will immunize mice per IACUC protocol instruction. The cost will include: 1 inoculation, 3 boosters, 2 in-life and 1 terminal blood collections. |
$1,600 | $1,440 | $2,400 | $3,000 |
| Primary Mouse DRG Cultures The DRGs are extracted from mouse spinal column and then digested with collagenase and papain to obtain single cell suspensions. The cells are then cultured on PDL-coated coverslips for the purpose of calcium imaging experiments. In addition, DRG cultures can also be treated with various compounds and the supernatants can be collected and analyzed for factors that are produced by DRG cells under different conditions. DRGs are sensory neurons so these cultures allows for the study of pain pathways. The charge is $500 for bilateral (up to 6 DRGs per animal) |
$500 | $450 | $750 | $1,000 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
In Vivo Toxicology Study – Acute Studies will include acute toxicology tests (MTD) to identify potential toxicity of newly synthesized drugs by behavioral observation. The cost is for one single compound treatment, for additional compounds use service 3. Blood and organ collection will be extra. |
$300 | $270 | ||
| In Vivo Toxicology Study – Repeat Dose To determine toxicity likely to arise from repeated exposures of a compound with repeat daily drug administration. Service includes daily monitoring of body weights and clinical observations. The cost is per week for one compound treatment. For additional compounds use service 3. Blood and organ collection will be extra. |
$350 | $315 | $525 | $700 |
| Drug Administration (PO, IP, SC) Provide drug treatment via oral gavage, intraperitoneal, or subcutaneous. Cost is per dose per animal. |
$45 | $40.50 | $67.50 | $90 |
| In Vivo Pharmacokinetics Study with Necropsy – Mouse Provide drug treatment via oral gavage, intraperitoneal, or subcutaneous. Cost is per dose per animal. |
$150 | $135 | $225 | $300 |
| In Vivo Pharmacokinetics Study with Necropsy – Rat DTC personnel will administer the test agent (PO, IP, SC) to rats. Organs and blood (whole blood, serum, or plasma) will be collected. Price per animal includes ≤ 5 major organs and one blood collection at ≤ 6 time points. There would be extra charge of $25 for each additional time point and IV injection (per animal). Surcharges will apply for brain collection ($5), specific brain region dissection ($10), and organ weights ($5). |
$175 | $157.50 | $262.50 | $350 |
| In Vivo Pharmacokinetics Study – Mouse DTC personnel will administer the test agent (PO, IP, SC). Blood (whole blood, serum, or plasma) will be collected at various time points. Price per animal includes terminal blood collection at ≤ 6 time points. There would be extra charge of $25 for each additional time point and IV injection (per animal). |
$100 | $90 | $150 | $200 |
| In Vivo Pharmacokinetics Study – Rat DTC personnel will administer the test agent (PO, IP, SC). Blood (whole blood, serum, or plasma) will be collected at various time points. Price per animal includes terminal blood collection at ≤ 6 time points. There would be extra charge of $25 for each additional time point and IV injection (per animal). |
$125 | $112.50 | $187.50 | $250 |
| Sample & Standard Curve (for PK Analysis) DTC personnel will perform tisse extration and prepare the standard curve for a given compound per IMSERC protocol requirement. The cost includes IMSERC submission. |
$20 | $18 | $30 | $40 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
Intravenous Compound Administration Provide drug treatment via intravenous injections. Cost is per dose per animal. |
$65 | $58.50 | $97.50 | $130 |
| Perfusion Animal will be perfused with a fixative and required organs are collected for immunohistochemistry analysis. |
$50 | $45 | $75 | $100 |
| Mini-pump Implantation – IP DTC personnel will prime and implant the miniosmotic pump for continous and controlled drug administration in the peritoneum cavity. Cost is for 1 pump/animal. Pump cost will be a passthrough. |
$200 | $180 | $300 | $400 |
| Mini-pump Implantation – SC DTC personnel will prime and implant the miniosmotic pump for continous and controlled drug administration under animal skin. Cost is for 1 pump/animal. Pump cost will be a passthrough. | $150 | $135 | $225 | $300 |
| Cranial Device Implantation Cost associated with a head implantation of a diagnositic device. Testing (technician) time is aadditional $130/hr-Analgesics injections are charged extra |
$200 | $180 | $300 | $400 |
| Subcutaneous Device Implantation Subcutaneous Implantation of a diagnostic devices or polymers. Charge includes retrieval of the device at the end of the study. Device testing assistance is charged $130/hr. Organ collection is a separate service. Analgesics injections are charged extra. |
$150 | $135 | $225 | $300 |
|
Service |
Northwestern User |
Cancer Center User |
Non-NU Academic User |
Commercial User |
|---|---|---|---|---|
|
IC50 Testing for NCI-60 Cell Lines DTC personnel will run the IC50 experiment for one compound in all NCI-60 cell lines (5-7 concentrations). |
$275 | $275 | $412.50 | $550 |
| PDX Model Development Consultation and labor to develop new patient-derived cancer models for researchers. |
$980 | $980 | $1470 | $1960 |
| Original PDX Tumor Usage Includes cost for long term storage of liquid nitrogen, characterization of PDX tumor by histology evaluation and molecular profiling. |
$375 | $375 | $562.50 | $750 |
| Image Analysis, Whole Tissue Slide – Setup Fee Visiopharm image analysis software, the service charges will include two parts: set up fee per project. |
$220 | $220 | $330 | $440 |
| Image Analysis, Whole Tissue Slide – Single Staining Visiopharm image analysis software, the service charges will include two parts single staining. |
$25 | $25 | $37.50 | $50 |
| Image Analysis, Whole Tissue Slide-Double Biomarker Staining or Tissue Microarray (TMA) Visiopharm image analysis software, the service charges will include Double biomarker staining or tissue microarray (TMA). |
$45 | $45 | $67.50 | $90 |